https://doi.org/10.4081/amsa.2023.36
Levosimendan off-label successfully used in two patients with exacerbated COPD and severe bronchospasm: a case series focusing on an explorative review of the current literature
Submitted: 28 September 2023
Accepted: 7 November 2023
Published: 17 November 2023
Accepted: 7 November 2023
Abstract Views: 418
PDF: 115
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Levosimendan was used off label to treat two patients with similar clinical and medical history (severe COPD, bronchospasm, cigarette smoking, difficult weaning). Starting from these two favorable cases, an explorative review of the current literature was conducted relating to this use of Levosimendan and its rationale.
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Babik B, Balogh AL, Sudy R, et al. Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits. Am J Physiol Lung Cell Mol Physiol 2017;313:L950-L956.
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Doorduin J, Sinderby CA, Beck J, et al. The calcium sensitizer levosimendan improves human diaphragm function. Am J Respir Crit Care Med 2012;185:90-5.
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How to Cite
Golino, L., Caiazzo, M., Diglio, P., Tornincasa, E., Russo, G., & Imperatore, F. (2023). Levosimendan off-label successfully used in two patients with exacerbated COPD and severe bronchospasm: a case series focusing on an explorative review of the current literature. Acute Care Medicine Surgery and Anesthesia, 1(1). https://doi.org/10.4081/amsa.2023.36
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